This research examines how a high-fat diet impacts immune responses in colorectal cancer.
Investigated the relationship between high-fat diet and immune responses in colorectal cancer models.
Analyzed the upregulation of CD155 in tumor environments influenced by dietary fat.
Evaluated the effects of metabolic stress on immune checkpoint blockade efficacy.
High-fat diet leads to increased CD155 expression in colorectal tumors.
Immune suppression was observed, potentially diminishing the effectiveness of immune checkpoint blockade therapy.
Obesity-related metabolic stress contributes to tumor immune evasion.
Abstract
Background Obesity-induced metabolic stress impairs the efficacy of immune checkpoint blockade (ICB) therapy, but the mechanisms linking a high-fat diet (HFD) to immune suppression remain unclear.