ABSTRACT Objective To clarify the difference in clinical efficacy between centrifugation filtration plasmapheresis (CFPP) and plasma exchange (PE) in treating hypertriglyceridemia‐induced acute pancreatitis (HTG‐AP). Methods Cases of HTG‐AP from January 2024 to May 2024 of First Medical Center of Chinese People's Liberation Army (PLA) General Hospital were included and divided into CFPP and PE groups based on the treatment. Medical records were reviewed to collect data on patient outcomes, clinical features, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and laboratory parameters before and after the treatment of CFPP or PE. The primary outcomes were discharge conditions, length of hospital stay (LOS) and serum triglycerides (TGs) reduction rate. Secondary outcomes were the incidence of complications (renal failure, gastrointestinal bleeding, shock, pulmonary failure, pancreatic cyst, and further surgical treatment). The correlation of initiation time of blood purification and patient outcomes was also examined. Furthermore, the patients with APACHE II score 0.05). Both CFPP and PE could effectively reduce serum TG (70.72% vs. 78.8%, p = 0.565). No significant correlation between initiation time and patient outcomes was observed ( p > 0.05). When patients with APACHE II scores 0.05). Conclusions CFPP and PE express similar efficacy in the treatment of HTG‐AP patients and could effectively reduce serum TG.
Yang et al. (Sun,) studied this question.