Efficacy Comparison of Centrifugation Filtration Plasmapheresis and Plasma Exchange in Hyperlipidemic Acute Pancreatitis Patients

Objective To clarify the difference in clinical efficacy between centrifugation filtration plasmapheresis (CFPP) and plasma exchange (PE) in treating hypertriglyceridemia‐induced acute pancreatitis (HTG‐AP). Methods Cases of HTG‐AP from January 2024 to May 2024 of First Medical Center of Chinese People's Liberation Army (PLA) General Hospital were included and divided into CFPP and PE groups based on the treatment. Medical records were reviewed to collect data on patient outcomes, clinical features, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and laboratory parameters before and after the treatment of CFPP or PE. The primary outcomes were discharge conditions, length of hospital stay (LOS) and serum triglycerides (TGs) reduction rate. Secondary outcomes were the incidence of complications (renal failure, gastrointestinal bleeding, shock, pulmonary failure, pancreatic cyst, and further surgical treatment). The correlation of initiation time of blood purification and patient outcomes was also examined. Furthermore, the patients with APACHE II score < 15 were analyzed separately. Results A total of 26 patients were included; the basic characteristics of patients in the CFPP group and PE group were similar. There were no significant differences in patients' discharge conditions, LOS, or incidence of complications (renal failure, gastrointestinal bleeding, shock, pulmonary failure, pancreatic cyst) between CFPP and PE groups ( p > 0.05). Both CFPP and PE could effectively reduce serum TG (70.72% vs. 78.8%, p = 0.565). No significant correlation between initiation time and patient outcomes was observed ( p > 0.05). When patients with APACHE II scores < 15 were analyzed, there were no significant differences observed in patient outcomes between the CFPP group and PE group ( p > 0.05). Conclusions CFPP and PE express similar efficacy in the treatment of HTG‐AP patients and could effectively reduce serum TG.