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Review highlights risk factors and assessment methods for opioid-induced hyperalgesia, suggesting implications for pain management strategies.
The review is devoted to the problem of opioid-induced hyperalgesia – a paradoxical effect in which therapy with narcotic analgesics can increase existing pain. The review considers the epidemiology, risk factors, mechanisms of development, differential diagnostics, recommendations for assessment and measures aimed at stopping the phenomenon of opioid-induced hyperalgesia.
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Spasova et al. (2025) studied this question.
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