What question did this study set out to answer?

To explore the problem of opioid-induced hyperalgesia and its associated factors.

December 23, 2025Podderživaûŝaâ terapiâ v onkologii.0 citationsOpen Access

Opioid-induced hyperalgesia

ASArina P. SpasovaPetrozavodsk State University ADA. M. DorozhenkoPetrozavodsk State University АРАлла Алексеевна РязанкинаMinistry of Health of the Russian Federation

Key Points

To explore the problem of opioid-induced hyperalgesia and its associated factors.
Review of existing literature on opioid-induced hyperalgesia
Analysis of epidemiology and risk factors
Discussion of mechanisms and differential diagnostics
Recommendations for assessment methods
proposed measures to mitigate the phenomenon.
Opioid-induced hyperalgesia is a paradoxical effect of narcotic analgesic therapy
Identifies various risk factors associated with opioid-induced hyperalgesia
Highlights the importance of accurate assessment methods
Suggests measures for clinicians to address and limit this phenomenon.

Abstract

The review is devoted to the problem of opioid-induced hyperalgesia – a paradoxical effect in which therapy with narcotic analgesics can increase existing pain. The review considers the epidemiology, risk factors, mechanisms of development, differential diagnostics, recommendations for assessment and measures aimed at stopping the phenomenon of opioid-induced hyperalgesia.

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