What question did this study set out to answer?

This research aims to enhance tumor-specific delivery of siRNA through engineered dendrimers.

January 6, 2026Biomaterials Science0 citations

Glutathione-Activatable Bola Dendrimers Mediate Tumor-Specific Cytosolic siRNA Delivery via Dynamic Thiol-Disulfide Exchange

DZDandan ZhuChina Pharmaceutical University HZHuiling ZhuChina Pharmaceutical University YYYaoyun YuChina Pharmaceutical University

Key Points

This research aims to enhance tumor-specific delivery of siRNA through engineered dendrimers.
Engineered glutathione-responsive bola dendrimers for delivering siRNA
Examined cytosolic delivery efficiency
Analyzed the role of dynamic thiol-disulfide exchange in delivery process.
Demonstrated improved siRNA delivery specifically to tumor cells
Showed release of siRNA in the cytosol facilitated by glutathione
Highlighted the potential of RNAi-driven therapies in precision cancer treatment.

Abstract

Effective delivery of small interfering RNA (siRNA) to the cytosol continues to pose a significant challenge in RNA interference (RNAi)-driven precision cancer therapy. In this study, we engineered glutathione (GSH)-responsive...

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