What question did this study set out to answer?

To investigate the association of the rs10191329 allele with age-related brain atrophy beyond multiple sclerosis.

January 6, 2026Annals of Neurology0 citations

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis

CCCato E. A. CorstenErasmus MC AMAna M. MarquesErasmus MC EVElisabeth J. VinkeErasmus MC

Key Points

To investigate the association of the rs10191329 allele with age-related brain atrophy beyond multiple sclerosis.
Analyzed 10,308 MRI scans from 4,815 participants aged 45 and older without MS
Conducted both cross-sectional and longitudinal analyses
Measured total brain volume and gray matter volume in participants
Observed lower total brain volume and gray matter volume in individuals with the rs10191329 allele
Findings were significant in participants younger than 55 years
Indicated that rs10191329 allele contributes to earlier brain atrophy onset

Abstract

The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age‐related brain atrophy in a population‐based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross‐sectional and longitudinal analyses. We observed associations between the rs10191329*A allele and lower total brain volume and gray matter volume in middle‐aged (< 55 years of age), but not in older participants. These data suggest that rs10191329*A contributes to earlier onset of atrophy in the general population, and that mediating mechanisms of accelerated neurodegeneration extend beyond MS. ANN NEUROL 2026

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