Baicalin protects against heat-induced multiorgan dysfunction via organ-specific protein modulation: integrative in silico and in vivo evidence

Key Points

• The aim is to explore the protective effects of Baicalin on heatstroke-induced multiorgan dysfunction.
• Conducted in silico analyses to evaluate protein interactions.
• Performed in vivo studies to assess Baicalin's impact on multiorgan dysfunction.
• Monitored systemic oxidative stress and inflammation markers.
• Baicalin significantly reduced inflammation associated with heatstroke.
• Improved organ function was noted in pre-treated models.
• Demonstrated potential therapeutic strategy against systemic oxidative stress.