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Shows reduced stroke risk with surgical left atrial appendage occlusion in patients with atrial fibrillation, indicating enhanced protection alongside antithrombotic therapy.
Among participants with atrial fibrillation who had undergone cardiac surgery, most of whom continued to receive ongoing antithrombotic therapy, the risk of ischemic stroke or systemic embolism was lower with concomitant left atrial appendage occlusion performed during the surgery than without it. (Funded by the Canadian Institutes of Health Research and others; LAAOS III ClinicalTrials.gov number, NCT01561651.).
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Whitlock et al. (2021) studied this question.
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