Heart failure accounted for 2.2% of total hospital admissions across LMICs, with an average in-hospital mortality of 8% and heterogeneous management practices observed.
Systematic Review (n=237,908)
Yes
237,908 episodes of heart failure from 42 studies on acute hospital care (232,550 patients) and 11 studies on chronic heart failure in primary care or outpatient settings (5,358 patients) across 31 low- and middle-income countries. Mean age 63 years, 58% male.
Presentation, causes, management, and outcomes (including in-hospital mortality and length of stay) of heart failure
Heart failure in low- and middle-income countries is characterized by high in-hospital mortality and suboptimal use of guideline-directed medical therapies, emphasizing the need for improved global management strategies.
p-value: p=<0.001
The presentation, underlying causes, management, and outcomes of heart failure vary substantially across LMICs. On average, the use of evidence-based medications tends to be suboptimal. Better strategies for heart failure surveillance and management in LMICs are needed. Please see later in the article for the Editors' Summary.
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Thomas Callender
University of Cambridge
Mark Woodward
Université Claude Bernard Lyon 1
Gregory A. Roth
General Cardiology
PLoS Medicine
Scopus
University of Washington
University of Oxford
The University of Queensland
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Callender et al. (Tue,) conducted a systematic review in Heart Failure (n=237,908). Angiotensin-converting enzyme inhibitors vs. none was evaluated on In-hospital mortality rate (95% CI 6%-10%, p=<0.001). Heart failure accounted for 2.2% of total hospital admissions across LMICs, with an average in-hospital mortality of 8% and heterogeneous management practices observed.
synapsesocial.com/papers/6961956115d481f6dda30a93 — DOI: https://doi.org/10.1371/journal.pmed.1001699