Heart failure accounted for 2.2% of total hospital admissions across LMICs, with an average in-hospital mortality of 8% and heterogeneous management practices observed.
Systematic Review (n=237,908)
Yes
Heart failure in low- and middle-income countries is characterized by high in-hospital mortality and suboptimal use of guideline-directed medical therapies, emphasizing the need for improved global management strategies.
p-value: p=<0.001
The presentation, underlying causes, management, and outcomes of heart failure vary substantially across LMICs. On average, the use of evidence-based medications tends to be suboptimal. Better strategies for heart failure surveillance and management in LMICs are needed. Please see later in the article for the Editors' Summary.
Callender et al. (2014) conducted a systematic review in Heart Failure (n=237,908). Angiotensin-converting enzyme inhibitors vs. none was evaluated on In-hospital mortality rate (95% CI 6%-10%, p=<0.001). Heart failure accounted for 2.2% of total hospital admissions across LMICs, with an average in-hospital mortality of 8% and heterogeneous management practices observed.