Key result
Administration of MR16-1 reduced left ventricular remodelling after myocardial infarction in mice by suppressing myocardial inflammation.
Why the study?
Does MR16-1 (antibody against interleukin-6 receptor) attenuate left ventricular remodelling in mice after myocardial infarction?
Population
Mice after myocardial infarction
Design
Preclinical
Authors
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May attenuate post-MI remodeling in mice via IL-6 blockade; leaves open translation to human therapy.
Does MR16-1 (antibody against interleukin-6 receptor) attenuate left ventricular remodelling in mice after myocardial infarction?
In a mouse model, neutralizing the IL-6 receptor with MR16-1 suppressed inflammation and attenuated left ventricular remodeling after myocardial infarction.
Kobara et al. (2010) studied this question. Administration of MR16-1 reduced left ventricular remodelling after myocardial infarction in mice by suppressing myocardial inflammation.
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