Key result
Multidisciplinary surgical management yields successful outcomes for familial thoracic aortic dissection in two pregnant siblings.
This case highlights the critical importance of early genetic identification, preconception counseling, and multidisciplinary surgical care in managing MYH11-associated heritable thoracic aortic disease during pregnancy.
Supports early genetic identification and multidisciplinary care in MYH11-related aortic disease in pregnancy; hypothesis-generating pending larger studies.
Two pregnant siblings presented with thoracic aortic dissection during the second trimester. A pathogenic MYH11 was identified following the first sibling's diagnosis. The second sibling, previously known to be at risk but lost to follow-up, reengaged during pregnancy, tested positive for the familial variant, and dissected before her initial evaluation. This case highlights the importance of genetic diagnosis, surveillance, and multidisciplinary care in managing heritable thoracic aortic disease during pregnancy.
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Pohahau et al. (2026) studied Myosin Heavy Chain 11–Associated Familial Thoracic Aortic Aneurysm and Dissection (n=2). Successful management of familial thoracic aortic aneurysm and dissection in pregnant patients was demonstrated in the case of two siblings.
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