What does this research mean for the field?

Elevated anti-EBV antibody titers are present in serum prior to and throughout the clinical period of multiple sclerosis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research examines the link between Epstein-Barr virus (EBV) and multiple sclerosis (MS), focusing on pathogenesis and treatment options.

January 10, 2026Journal of Applied Genetics0 citations

Epstein–barr virus and multiple sclerosis: from pathogenesis and diagnosis to EBV-specific T cell therapy and gene-targeted therapeutics

MPMukesh PushkarnaGoa University AZAhmed ZwamelIraqi University SVSeema VermaJain University

Key Result

Elevated anti-EBV antibody titers are present in serum prior to and throughout the clinical period of multiple sclerosis.

Key Points

This research examines the link between Epstein-Barr virus (EBV) and multiple sclerosis (MS), focusing on pathogenesis and treatment options.
Reviewed existing literature on EBV infection and MS prevalence.
Analyzed anti-EBV antibody levels in MS patients.
Discussed potential T cell therapies and gene-targeted approaches.
Elevated anti-EBV antibodies were found in MS patients before and during the clinical phase.
EBV can infect and clone B cells, contributing to MS pathogenesis.
The relationship suggests avenues for EBV-specific T cell therapy and immune-targeted treatments.

Structured PICO

Population

Individuals with multiple sclerosis (MS)

The paper reviews the role of Epstein-Barr virus infection in the pathogenesis of multiple sclerosis and explores potential targeted therapies.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Multiple sclerosis (MS) is a central nervous system (CNS) disorder defined by inflammation, demyelination, and neuronal damage. Several independent studies have confirmed the prevalence of EBV infection in MS and the presence of elevated anti-EBV antibody titers in serum prior to and throughout the clinical period of MS. EBV stands out from other human-infecting viruses in that it can activate, infect, and clone the B cells and remain a latent infection inside them. The prevalence of EBV-positive B cell lymphoproliferative diseases in immunocompromised individuals demonstrates the critical significance of immune surveillance in managing EBV infection. It has also been postulated that a deficiency in EBV-specific CD8

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