LetibotulinumtoxinA-wlbg significantly improved the composite responder rate at week 4 compared to placebo (RR = 59.47; 95% CI: 14.95, 236.52) with no increased adverse events.
Does LetibotulinumtoxinA-wlbg improve the composite responder rate compared to placebo in adults with moderate-to-severe glabellar lines?
LetibotulinumtoxinA-wlbg is a highly effective and well-tolerated novel treatment for moderate-to-severe glabellar lines with sustained efficacy up to 16 weeks.
Absolute Event Rate: 0% vs 0%
BACKGROUND: Botulinum toxin type A injections are widely used for the aesthetic treatment of glabellar lines; however, data on the efficacy and safety of newer formulations remain limited. AIM: This systematic review and meta-analysis aims to assess the efficacy and safety of the novel botulinum toxin LetibotulinumtoxinA-wlbg compared to placebo for treating moderate-to-severe glabellar lines. METHODS: A systematic literature search was conducted to identify randomized controlled trials (RCTs) comparing LetibotulinumtoxinA-wlbg with placebo in adults. A meta-analysis was performed using random-effects models, and the Cochrane RoB-2 tool was used to assess the risk of bias. RESULTS: Three RCTs including 1272 patients were analyzed. LetibotulinumtoxinA-wlbg was significantly more effective than placebo for the primary outcome, the composite responder rate at week 4 (risk ratio RR = 59.47; 95% CI: 14.95, 236.52). Sustained efficacy was observed at weeks 12 and 16, with significant improvements also seen in investigator-assessed, subject-assessed, and psychological outcomes. The safety analysis revealed no significant increase in the risk of serious, non-serious, or overall treatment-emergent adverse events. CONCLUSIONS: LetibotulinumtoxinA-wlbg is an efficacious and well-tolerated treatment for moderate-to-severe glabellar lines. The therapeutic effect is durable, with statistically significant efficacy maintained at 12 and 16 weeks post-treatment. Treatment results in a significant improvement in patients' psychological well-being related to their facial appearance. The safety profile is favorable, with no statistically significant increase in the risk of serious or non-serious adverse events compared to placebo. Further research, including direct head-to-head trials, is warranted to establish its comparative effectiveness. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Masood et al. (Wed,) reported a other. LetibotulinumtoxinA-wlbg significantly improved the composite responder rate at week 4 compared to placebo (RR = 59.47; 95% CI: 14.95, 236.52) with no increased adverse events.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: