What question did this study set out to answer?

To detail a case of jejunal angiosarcoma presenting with severe anemia and metastatic disease.

January 10, 2026Frontiers in Oncology0 citationsOpen Access

Primary epithelioid angiosarcoma of the jejunum presenting with severe anemia and distant metastasis: a case report and literature review

SLShurong LiuPeking University JZJunling ZhangPeking University XWXin WangPeking University

Key Result

A 72-year-old man with jejunal angiosarcoma presented with severe anemia and lung and bone metastases, confirmed by IHC positivity for CD31, CD34, and ERG.

Key Points

To detail a case of jejunal angiosarcoma presenting with severe anemia and metastatic disease.
Reported a case involving a 72-year-old man with melena and anemia.
Utilized plain CT for initial assessment and small enteroscopy for lesion localization.
Conducted partial small bowel resection followed by pathological examination.
Used immunohistochemical staining for tumor characterization.
Diagnosed jejunal angiosarcoma associated with lung and bone metastases.
Stabilization of hemoglobin achieved through various interventions.
Pathological examination confirmed angiosarcoma invasion in the intestinal wall.
Immunohistochemical results showed strong CD31 positivity.

Structured PICO

Population

1 patient, 72-year-old man with primary epithelioid angiosarcoma of the jejunum presenting with severe anemia and distant metastasis.

Intervention

Partial small bowel resection and side-to-side anastomosis

Jejunal angiosarcoma is a rare, highly aggressive malignancy with a poor prognosis, often presenting with non-specific symptoms like gastrointestinal bleeding and requiring comprehensive evaluation and multidisciplinary management.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Angiosarcoma (AS), constituting approximately 2% of all soft tissue sarcomas, is an aggressive endothelial malignancy. We report on the case of a 72-year-old man admitted with persistent melena and severe anemia, ultimately diagnosed with jejunal angiosarcoma (JAS) and associated lung and bone metastases. Temporary stabilization of his hemoglobin level was achieved via fasting, hemostasis, and blood transfusion. The initial plain CT identified multifocal solid lung nodules, but failed to reveal a primary digestive system lesion. Subsequent small enteroscopy localized a submucosal bulge in the jejunum, 70 cm from the pylorus. Following partial small bowel resection, the pathological examination confirmed a 0.9-cm × 0.8-cm × 0.7-cm angiosarcoma invading the intestinal wall and lamina propria. Immunohistochemical (IHC) staining showed strong positivity for CD31(++), alongside CD34(vascular+) and ERG(+). This report reviews the recent literature on JAS, summarizing the diagnostic and therapeutic strategies.

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