Key result
Jejunal angiosarcoma presents with severe anemia and metastases in a 72-year-old man.
Why the study?
Angiosarcoma is an aggressive endothelial malignancy, and this report summarizes diagnostic and therapeutic strategies for jejunal angiosarcoma through a case presentation and literature review.
Jejunal angiosarcoma is a rare, highly aggressive malignancy with a poor prognosis, often presenting with non-specific symptoms like gastrointestinal bleeding and requiring comprehensive evaluation and multidisciplinary management.
Highlights diagnostic challenges of rare jejunal angiosarcoma; extends sparse case reports but leaves optimal management open.
Angiosarcoma (AS), constituting approximately 2% of all soft tissue sarcomas, is an aggressive endothelial malignancy. We report on the case of a 72-year-old man admitted with persistent melena and severe anemia, ultimately diagnosed with jejunal angiosarcoma (JAS) and associated lung and bone metastases. Temporary stabilization of his hemoglobin level was achieved via fasting, hemostasis, and blood transfusion. The initial plain CT identified multifocal solid lung nodules, but failed to reveal a primary digestive system lesion. Subsequent small enteroscopy localized a submucosal bulge in the jejunum, 70 cm from the pylorus. Following partial small bowel resection, the pathological examination confirmed a 0.9-cm × 0.8-cm × 0.7-cm angiosarcoma invading the intestinal wall and lamina propria. Immunohistochemical (IHC) staining showed strong positivity for CD31(++), alongside CD34(vascular+) and ERG(+). This report reviews the recent literature on JAS, summarizing the diagnostic and therapeutic strategies.
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Liu et al. (2026) studied this question. A 72-year-old man with jejunal angiosarcoma presented with severe anemia and lung and bone metastases, confirmed by IHC positivity for CD31, CD34, and ERG.
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