What does this research mean for the field?

Admission dysglycemia is associated with attenuated early LVEF recovery after PPCI, with effects persisting through 90 days. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the relationship between admission dysglycemia and early cardiac recovery metrics post-percutaneous coronary intervention (PPCI).

January 10, 2026Cardiovascular Diabetology – Endocrinology Reports0 citationsOpen Access

From metabolism to myocardium: the missing link of admission dysglycemia in early cardiac recovery

FKFahad R KhanUniversity of Peshawar FAFazal E AkbarUniversity of Peshawar KAKamran AslamUniversity of Peshawar

Key Result

Admission dysglycemia was associated with attenuated early LVEF recovery after PPCI, with effects persisting through 90 days.

Key Points

This research aims to investigate the relationship between admission dysglycemia and early cardiac recovery metrics post-percutaneous coronary intervention (PPCI).
Analyzed association between admission dysglycemia and LVEF recovery after PPCI.
Evaluated long-term signals up to 90 days post-intervention.
Utilized HbA1c-anchored stress-adjusted indices for profiling.
Identified that admission dysglycemia is linked to reduced early LVEF recovery.
Signals of dysglycemia persisted through 90 days post-PPCI.
Demonstrated potential quickening of early major adverse cardiac events (MACE) due to dysglycemia.

Structured PICO

Does admission dysglycemia attenuate early LVEF recovery in STEMI patients undergoing PPCI?

Population

600 consecutive adults with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), mean age 59.8, 65.7% male, based in Pakistan. Key exclusions: prior non-ischemic cardiomyopathy, severely reduced LVEF, missing admission glucose or HbA1c, or absent/nondiagnostic echocardiograms.

Intervention

Poor or intermediate admission glycemic control (assessed via admission glucose, HbA1c, stress hyperglycemia ratio [SHR], and glycemic gap)

Comparator

Good admission glycemic control

Outcome

Follow-up left ventricular ejection fraction (LVEF) within 7 dayssurrogate

Admission dysglycemia and stress hyperglycemia are associated with attenuated early LVEF recovery and higher short-term MACE in STEMI patients undergoing PPCI.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Admission dysglycemia, including stress-adjusted indices, was associated with attenuated early LVEF recovery after PPCI, with signals persisting through 90 days and aligning with early MACE. In practice, routine HbA1c-anchored stress-adjusted profiling at presentation may refine risk stratification and support protocolized inpatient glucose management.

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