Key result
Moderate-to-severe depressive symptoms affect ~72% of HF patients, linked to poor sleep via fatigue and isolation.
Why the study?
This study aimed to evaluate the rate of depressive symptoms and the interrelationships among sleep quality, fatigue, social isolation, and depressive symptoms in patients with HF in China.
In patients with heart failure, poor sleep quality is associated with depressive symptoms, a relationship that is mediated by fatigue and social isolation.
Supports screening for depressive symptoms in heart failure; extends mediation models but leaves causal inference open for prospective trials.
This study aimed to assess the rate of depressive symptoms and the interrelationships among sleep quality, fatigue, social isolation, and depressive symptoms in patients with heart failure (HF) in China. A cross-sectional study at a general hospital, 300 patients with HF were conveniently sampled from January to March 2024. To measure whether fatigue and social isolation mediated the association between sleep quality and depressive symptoms, descriptive analysis, Pearson correlation, and parallel mediation analyses were conducted via SPSS 26.0. Results showed that 72.3% of the participants had moderate to severe depressive symptoms. Fatigue and social isolation parallelly mediated the relationship between sleep quality and depressive symptoms. These findings highlight the prevention and management of depressive symptoms in HF patients. Future studies need to design and evaluate the effectiveness of interventions that incorporate multiple components on targeting sleep quality, social isolation, and fatigue in patients with HF.
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Guan et al. (2026) studied this question. In patients with heart failure, 72.3% had moderate to severe depressive symptoms, with fatigue and social isolation mediating the link to poor sleep quality.
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