What question did this study set out to answer?

The study aims to explore how health-related quality of life varies between genders among patients with acute coronary syndrome.

January 10, 2026Cureus0 citationsOpen Access

Gender-Based Differences in Health-Related Quality of Life Among Acute Coronary Syndrome Patients: A Cross-Sectional Study

YGYoshita GuptaJaipur National University DUDinesh Kumar UpadhyayJaipur National University ACAbhay ChaudharySawai ManSingh Medical College and Hospital

Key Points

The study aims to explore how health-related quality of life varies between genders among patients with acute coronary syndrome.
Conducted a cross-sectional analysis of acute coronary syndrome patients

Structured PICO

Population

157 adults aged ≥18 years diagnosed with acute coronary syndrome (ACS) who underwent percutaneous transluminal coronary angioplasty (PTCA) and were on continuous antiplatelet medication for at least 90 days. Mean age 57.38 years, 65.6% male, based in India.

Intervention

Percutaneous transluminal coronary angioplasty (PTCA) followed by at least 90 days of continuous antiplatelet medication

Outcome

Health-related quality of life (HRQoL) measured by the Short Form Health Survey 12-item (SF-12v2) Physical Component Summary (PCS) and Mental Component Summary (MCS) scorespatient reported

ACS substantially impairs physical and mental health-related quality of life post-PTCA, with older age, male gender, and lower socioeconomic status predicting worse physical outcomes in an Indian cohort.

Abstract

Background Acute coronary syndrome (ACS) significantly affects patients' health-related quality of life (HRQoL). However, limited data exist on HRQoL outcomes following percutaneous transluminal coronary angioplasty (PTCA) in rural Indian populations. This study aimed to assess HRQoL among post-PTCA ACS patients. Methods This cross-sectional study evaluated HRQoL in 157 patients with ACS who underwent PTCA at a tertiary care hospital between July 2025 and September 2025. Data were collected using the Short Form Health Survey 12-item (SF-12®v2) questionnaire through convenience sampling. Descriptive statistics, Chi-square tests, and multivariate regression analyses were conducted to explore associations between HRQoL outcomes and sociodemographic variables. Results The mean Physical Component Summary (PCS) score was 36.19 ± 8.37, and the Mental Component Summary (MCS) score was 42.19 ± 10.22. Male patients exhibited higher PCS scores (36.54 ± 8.41) and lower MCS scores (40.89 ± 10.20) compared to female patients (PCS: 35.54 ± 8.34; MCS: 43.41 ± 9.51). A significant association was found between sociodemographic variables and HRQoL scores (p < 0.001). Multivariate regression analysis identified age, gender, and occupation as significant predictors of PCS. Conclusion ACS substantially impairs HRQoL, particularly among older adults, males, and individuals with lower socioeconomic status. Integrating routine HRQoL assessments and implementing targeted interventions (such as physical rehabilitation, gender-specific psychosocial support, and strategies to mitigate socioeconomic barriers) are essential for improving long-term outcomes and fostering patient-centered care in ACS management.

Ask AI

Helpful

Bookmark

View Full Paper