What does this research mean for the field?

Plasma 14-3-3 epsilon levels are associated with right ventricular dysfunction in patients with pulmonary hypertension. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To investigate the relationship between 14-3-3 epsilon and right ventricular failure in pulmonary hypertension.

January 10, 2026Internal Medicine0 citationsOpen Access

Significance of 14-3-3 Epsilon for Right Ventricular Failure Associated with Pulmonary Hypertension

TYTetsuro Yokokawa KNKazuto NishiuraFukushima Medical University JAJoh AkamaFukushima Medical University

Key Result

Plasma 14-3-3 epsilon levels are associated with right ventricular dysfunction in patients with pulmonary hypertension.

Key Points

To investigate the relationship between 14-3-3 epsilon and right ventricular failure in pulmonary hypertension.
Measured plasma levels of 14-3-3 epsilon in patients with pulmonary hypertension
Assessed right ventricular function through clinical evaluations
Established a significant association between higher plasma 14-3-3 epsilon levels and right ventricular failure
Identified 14-3-3 epsilon as a potential biomarker for evaluating right ventricular dysfunction

Structured PICO

Does measurement of plasma 14-3-3 epsilon improve evaluation of right ventricular dysfunction in patients with pulmonary hypertension?

Population

83 patients with pulmonary hypertension (15 with pulmonary arterial hypertension, 68 with chronic thromboembolic pulmonary hypertension) and 5 healthy controls. Also included monocrotaline-induced PH rat models and Sugen/hypoxia-induced PH mouse models.

Intervention

Measurement of plasma 14-3-3 epsilon levels; a subset of 25 CTEPH patients underwent balloon pulmonary angioplasty.

Comparator

Healthy control subjects (n=5) and baseline measurements prior to balloon pulmonary angioplasty.

Outcome

Association between plasma 14-3-3 epsilon levels and right ventricular dysfunction (tricuspid lateral annular peak systolic velocity and right ventricular fractional area changes).surrogate

Plasma 14-3-3 epsilon is a potential novel circulating biomarker for evaluating right ventricular dysfunction in patients with pulmonary hypertension.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

This is the first study to demonstrate an association between 14-3-3 epsilon and right ventricular failure. Plasma 14-3-3 epsilon level may be a useful circulating marker for evaluating right ventricular dysfunction in patients with pulmonary hypertension.

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