What question did this study set out to answer?

This research aims to investigate the relationship between renin-independent aldosteronism and renal impairment in Chinese adults.

January 10, 2026Kidney Medicine0 citationsOpen Access

Renin-Independent Aldosteronism Heightened the Risk of Renal Impairment in Chinese Adults from Hakka Biobank

JLJingwei LinGuangxi Medical University FFFuxiang FangGuangxi Medical University SHShengzhu HuangGuangxi Medical University

Key Points

This research aims to investigate the relationship between renin-independent aldosteronism and renal impairment in Chinese adults.
Analyzed data from the Hakka Biobank

Structured PICO

Does renin-independent aldosteronism increase the risk of renal impairment compared to renin-dependent aldosteronism in Chinese Hakka adults?

Population

7,760 adults from the Hakka Biobank in Bobai County, Guangxi, China

Intervention

Renin-independent aldosteronism (defined by plasma aldosterone concentration and plasma renin concentration)

Comparator

Renin-dependent aldosteronism and control

Outcome

Kidney function impairment including urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and CKD-combination (moderate, high, or very high CKD risk according to 2024 KDIGO guidelines)surrogate

Renin-independent aldosteronism is associated with a higher risk of renal impairment compared to renin-dependent aldosteronism, highlighting the need for early screening and targeted intervention.

Abstract

Rationale findings are specific to the Hakka population. Conclusions: Renin-independent aldosteronism confers a higher risk of renal impairment than renin-dependent aldosteronism in the Chinese Hakka population, highlighting the need for early screening and targeted intervention in renin-independent aldosteronism.

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