What question did this study set out to answer?

To investigate the relationship between atherogenic index of plasma-frailty index (AIP-FI) and cardiovascular events.

January 10, 2026Cardiovascular Diabetology0 citationsOpen Access

Association between combined atherogenic and frailty index and cardiovascular events: evidence from the CHARLS cohort

GHGuijun HuoVascular Medicine YCYijia ChenFu Jen Catholic University YTYao TangDalian University of Technology

Key Result

Higher Atherogenic Index of Plasma-Frailty Index (AIP-FI) is significantly associated with increased cardiovascular disease, stroke, and heart disease risk.

Key Points

To investigate the relationship between atherogenic index of plasma-frailty index (AIP-FI) and cardiovascular events.
Utilized data from the CHARLS cohort to analyze cardiovascular outcomes.
Measured AIP-FI to assess metabolic and frailty aspects.
Evaluated associations with CVD, stroke, and heart disease.
Higher AIP-FI was significantly linked to an increased risk of cardiovascular disease.
AIP-FI correlated with higher rates of stroke and heart disease.
Findings support early risk assessment and intervention strategies.

Structured PICO

Does a higher combined atherogenic and frailty index (AIP-FI) increase the risk of cardiovascular disease, stroke, and heart disease in middle-aged and older adults?

Population

6,896 middle-aged and older adults aged ≥ 45 years from the CHARLS cohort in China, without a history of CVD, stroke, or heart disease at baseline. Mean age 58.0 years, 50.0% male.

Intervention

Higher Atherogenic index of plasma-frailty index (AIP-FI) score

Comparator

Lower AIP-FI score (lowest quartile Q1 as reference)

Outcome

Incident cardiovascular disease (CVD), stroke, and heart disease evaluated through self-reported physician diagnosishard clinical

The combined atherogenic and frailty index (AIP-FI) is a strong, independent predictor of cardiovascular disease, stroke, and heart disease in middle-aged and older adults, offering a novel tool for risk stratification.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Our study demonstrated that higher AIP-FI was significantly associated with increased risk of CVD, stroke, and heart disease. By integrating metabolic and frailty information, AIP-FI offers an effective and accessible tool for cardiovascular risk assessment, supporting earlier prevention and intervention strategies in the middle-aged and elderly Chinese populations.

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