Metabolically healthy obesity (MHO) was associated with a 33% lower risk of all-cause mortality compared to non-obese patients (OR: 0.67), while metabolically unhealthy obesity had no significant impa
Does metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUHO) impact all-cause mortality and cardiac arrest in elderly patients with cancer-related pulmonary embolism compared to non-obese patients?
In elderly patients with cancer-related pulmonary embolism, metabolically healthy obesity was associated with a lower risk of in-hospital all-cause mortality compared to non-obese patients, suggesting an obesity paradox.
Absolute Event Rate: 0% vs 0%
Background: Although obesity has been widely recognized as a risk factor for cardiovascular morbidity and mortality, distinguishing metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) introduces a nuanced perspective in managing cancer-related pulmonary embolism (PE) among older people. Therefore, this study aims to investigate whether MHO or MUHO phenotypes have a differential impact on in-hospital outcomes. Methods: Using the National Inpatient Sample (NIS) (2016 to 2020) and ICD-10 CM codes, we identified cancer-related PE hospitalizations in elderly (≥65 years) patients. The study evaluated the demographics, comorbidities, and outcomes of cancer-related PE hospitalizations in two groups: patients without obesity and obese patients with MHO and MUHO. The study assessed the adjusted odds of all-cause mortality and cardiac arrest as primary outcomes and healthcare resource utilization as a secondary outcome using multivariable regression analyses. Results: Of 211, 070 cancer-related pulmonary embolism (PE) admissions, 87. 5% were non-obese, 1. 4% were MHO, and 11% were MUHO. MHO patients were primarily female (64. 2%), younger (median age 71), and white (85. 5%). Medicare was the primary payer, and care was mainly provided in urban teaching hospitals (74%) and the South region (28. 9%). MUHO’s prevalence significantly rose from 9. 8% in 2016 to 11. 9% in 2020 compared to patients with MHO. Patients with MUHO had higher rates of comorbidities compared to other groups. Multivariable regression analysis revealed that patients with metabolically healthy obesity (MHO) demonstrate a significantly lower risk of all-cause mortality (OR: 0. 67, 95% confidence interval CI: 0. 59–0. 76) compared to non-obese patients. Conversely, patients with metabolically unhealthy obesity (MUHO) did not have a significant impact on mortality risk (OR: 0. 88, 95% CI: 0. 67–1. 15), all with P < 0. 001. Additionally, no significant differences in the rates of cardiac arrest were observed among MHO (OR: 1. 14, 95% CI: 0. 66–1. 98, P = 0. 892) or MUHO (OR: 1. 01, 95% CI: 0. 80–1. 26, P = 0. 892) patients when compared to non-obese individuals. Notably, patients with MHO experienced prolonged hospital stays (6 days) and incurred higher hospital expenses (63, 228) than other groups. Moreover, patients with MHO exhibited a higher likelihood of being discharged to a skilled nursing facility in comparison with patients with MUHO and those without obesity (28. 6% vs 25. 6% vs 23. 2%). Conclusions: In conclusion, despite the rise in the prevalence of metabolically unhealthy (MUHO) and healthy obesity (MHO), our study focusing on the elderly cohort of cancer patients complicated by PE found a paradoxical effect of obesity on all-cause mortality rates with both metabolically healthy and unhealthy obesity, suggesting a potential protective effect. These findings highlight the need for further research to understand better the mechanisms underlying these associations.
Neppala et al. (Wed,) reported a other. Metabolically healthy obesity (MHO) was associated with a 33% lower risk of all-cause mortality compared to non-obese patients (OR: 0.67), while metabolically unhealthy obesity had no significant impa.