Imbalances in circulating monocyte and high-density lipoprotein cholesterol exacerbates the residual risk of incident myocardial infarction beyond LDL-C: a real-life, prospective cohort study

Figures

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  Fig. 1. Cumulative incidence of myocardial infarction across CumMHR quartiles in the entire population. Quartile 1: Cumulative MHR quartile 1; Quartile 2: Cumulative MHR quartile 2; Quartile 3: Cumulative MHR quartile 3; Quartile 4: Cumulative MHR quartile 4

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  Fig. 2. Association between the CumMHR and incident myocardial infarction stratified by LDL-C level. P-interaction: CumMHR quartiles*LDL-C (< 1.8, 1.8 to 2.6, 2.6 to 3.4 or ≥ 3.4 mmol/L) = 0.0574. Covariables in the multivariable-adjusted model included sex (male or female, except for sex-stratified analysis), age (continuous, except for age-stratified analysis), BMI (continuous), smoking habits (never, ever, current), alcohol consumption (yes or no), education level (less than high school, high school and above), physical activity (infrequent, occasional, frequent), family history of CVD (yes or no), SBP (continuous), diabetes status (yes or no), antihypertensives (yes or no), antidiabetics (yes or no), lipid-lowering drugs (yes or no) and loghsCRP (continuous). The incidence rate is per 1,0000 person-years. Abbreviations are as in Table 1

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  Fig. 3. Association between the CumMHR and incident myocardial infarction stratified by sex or age. P-interaction: CumMHR quartiles *sex (male/female) = 0.5287; CumMHR quartile* age subgroups (< 55/≥55 years) = 0.2044. Covariables in the multivariable-adjusted model included sex (male or female, except for sex-stratified analysis), age (continuous, except for age-stratified analysis), BMI (continuous), smoking habits (never, ever, current), alcohol consumption (yes or no), education level (less than high school, high school and above), physical activity (infrequent, occasional, frequent), family history of CVD (yes or no), TC (continuous), SBP (continuous), diabetes (yes or no), antihypertensives (yes or no), antidiabetics (yes or no), lipid-lowering drugs (yes or no) and loghsCRP (continuous). The incidence rate is per 1,0000 person-years. Abbreviations are as in Table 1

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  Fig. 4. Association between the CumMHR and incident myocardial infarction stratified by prevalent disease or subclinical inflammation. P-interaction: CumMHR quartiles*hypertension (yes or no) = 0.1573; CumMHR quartiles*diabetes (yes or no) = 0.9947; CumMHR quartiles*dyslipidemia (yes or no) = 0.0691; CumMHR quartiles*renal dysfunction (yes or no) = 0.4947. Covariables in the multivariable-adjusted mode included sex (male or female), age (continuous), BMI (continuous), smoking habits (never, ever, current), alcohol consumption (yes or no), education level (less than high school, high school and above), physical activity (infrequent, occasional, frequent), family history of CVD (yes or no), TC (continuous, except for dyslipidemia-stratified analysis), SBP (continuous, except for hypertension-stratified analysis), diabetes status (yes or no, except for diabetes-stratified analysis), (yes or no), antidiabetics (yes or no), lipid-lowering drugs (yes or no) and loghsCRP (continuous, except for inflammation-stratified analysis). The incidence rate is per 1,0000 person-years. Abbreviations are as in Table 1