What does this research mean for the field?

Hypertension has no significant effect on primary restenosis after endovascular treatment. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the relationship between hypertension and restenosis following endovascular therapy.

January 10, 2026BMC Cardiovascular Disorders0 citationsOpen Access

Correlation between hypertension and restenosis after endovascular therapy: a meta-analysis based on a derived cohort from randomized trials

CZCheng Zhang YMYarong Ma QZQi Zhang

Key Result

Hypertension had no significant effect on primary restenosis after endovascular treatment (RR = 1.05, 95% CI: 0.86-1.27), suggesting no association.

Key Points

This research aims to evaluate the relationship between hypertension and restenosis following endovascular therapy.
Conducted a meta-analysis of randomized trial cohorts.
Analyzed outcomes based on various subgroups including antiplatelet duration and device type.
Assessed the certainty of evidence using a GRADE framework.
Hypertension had no significant effect on primary restenosis (RR = 1.05, 95% CI: 0.86-1.27).
Results were consistent across different subgroup analyses.
The certainty of evidence was rated as moderate, indicating need for cautious interpretation.

Structured PICO

Does hypertension increase the risk of primary restenosis in patients undergoing endovascular treatment?

Population

5,142 individuals from 6 randomized controlled trials undergoing endovascular treatment (PTA or stenting) for coronary or peripheral artery disease.

Intervention

Presence of hypertension (evaluated as a prognostic exposure factor)

Comparator

Absence of hypertension

Outcome

Primary restenosis (defined as a stenosis diameter exceeding 50% in the in-segment region, observed through angiography)surrogate

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

This meta-analysis of random trial cohorts revealed that hypertension had no significant effect on primary restenosis after endovascular treatment (RR = 1.05, 95% CI: 0.86-1.27), and the results were consistent across subgroups by antiplatelet duration, device type, and vascular bed; residual confounding could not be excluded. Using a GRADE framework adapted for prognostic factors, the overall certainty of evidence was moderate, and the results should be interpreted with caution. However, these findings are limited by the nonrandomized nature of the exposure, heterogeneity in endpoint definitions, and short follow-up, indicating a need for more robust prognostic studies.

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