FC patients exhibited increased alpha and reduced gamma during specific tasks, highlighting significant cortical oscillatory changes linked to brain-gut dysfunction.
Do patients with functional constipation exhibit altered cortical oscillatory dynamics compared to healthy controls?
Functional constipation is associated with specific task-dependent alterations in cortical oscillatory dynamics, supporting the role of brain-gut axis dysfunction.
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Functional constipation (FC) is a common functional gastrointestinal disorder thought to arise from the brain–gut axis dysfunction, yet direct human neurophysiological evidence is lacking. We recorded high-density electroencephalography (EEG) data in 21 FC patients and 37 healthy controls across resting, cognitive, and defecation-related tasks. We observed that FC patients displayed a consistent, task-dependent signature compared with healthy controls. At the regional level, FC patients exhibited increased alpha during both resting and defecation-related tasks, reduced temporal gamma during defecation-related tasks, as well as elevated temporal theta during the cognitive task. At the global level, we found altered network properties, such as global efficiency in the delta and beta band networks during resting and defecation-related tasks. These findings establish a direct neurophysiological link between specific, condition-dependent perturbations in cortical rhythm activity and FC pathophysiology. Our work implicates the brain–gut axis in symptom generation and opens a path toward EEG-based biomarkers and targeted neuromodulatory therapies.
Li et al. (Mon,) reported a other. FC patients exhibited increased alpha and reduced gamma during specific tasks, highlighting significant cortical oscillatory changes linked to brain-gut dysfunction.
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