Hydrogen sulfide attenuates PMA-Induced hypertrophy in human cardiomyocytes by modulating gene expression and reducing sulfide methylation

Key Result

Hydrogen sulfide reduced PMA-induced hypertrophy in human cardiomyocytes by modulating gene expression and decreasing sulfide methylation.

Key Points

• This research aims to determine how hydrogen sulfide affects hypertrophy in human cardiomyocytes and its mechanisms.
• Cultured human cardiomyocytes were treated with PMA and hydrogen sulfide.
• Gene expression levels were analyzed to assess changes due to hydrogen sulfide.
• Sulfide methylation was measured pre- and post-treatment.
• Hydrogen sulfide significantly reduced PMA-induced hypertrophy in cardiomyocytes.
• Alterations in gene expression related to hypertrophy were observed.
• Sulfide methylation levels decreased with hydrogen sulfide treatment.