Agari-5 improved cardiac function and reduced inflammation and fibrosis in rats with myocardial infarction, potentially linked to PSAT1, PDK1, SMAD4, and SDF2.
Does Agari-5 improve cardiac function and reduce myocardial injury in a rat model of myocardial infarction?
Agari-5 demonstrates protective effects against myocardial infarction in a rat model, potentially mediated through PSAT1, PDK1, SMAD4, and SDF2 pathways.
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BACKGROUND Myocardial infarction (MI) occupies a very high mortality and morbidity rate, and the search for effective pharmacological treatments has far-reaching implications for clinical research. AIM To explore the protective effects of Mongolian medicine Agari-5 on rats with MI. METHODS Sprague-Dawley rats were used, and both the Agari-5 and model groups had their coronary arteries clamped to induce MI. Proteomics was used to research the potential mechanism of action while ELISA, hematoxylin and eosin, and Masson’s staining were used to preliminarily investigate the protective impact of Agari-5 on rats with MI. RESULTS The current study has shown that Agari-5 might enhance cardiac function indicators, including echocardiography results of rats and creatine kinase, creatine kinase isoenzyme, and lactate dehydrogenase, in rats that had MI. According to the results of pathological staining, Agari-5 may lessen inflammatory cell infiltration and cardiomyocyte fibrosis, among other things. The proteome analysis revealed that there were 60 distinct proteins in total, four of which were associated with the heart. The expression of PSAT1, PDK1, SMAD4, and SDF2 proteins may be linked to the mechanism of their protective effects. CONCLUSION Potential therapeutic effects of Agari-5 for MI and its mechanism of action may be related to PSAT1, PDK1, SMAD4, and SDF2.
ZHAO et al. (Wed,) reported a other. Agari-5 improved cardiac function and reduced inflammation and fibrosis in rats with myocardial infarction, potentially linked to PSAT1, PDK1, SMAD4, and SDF2.