What does this research mean for the field?

Early surgical intervention in patients with infective endocarditis did not increase mortality or reoperation risk within one year. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The aim is to evaluate whether early surgical intervention affects mortality and recurrence in patients with infective endocarditis.

January 10, 2026Journal of Cardiothoracic Surgery0 citationsOpen Access

Cardiac surgery timing on the prognosis of patients with infective endocarditis

WLWu LiuNanchang University YLY. LiNanchang University HYHeng YangNanchang University

Key Result

Early surgical intervention in patients with infective endocarditis did not increase mortality or reoperation risk within one year.

Key Points

The aim is to evaluate whether early surgical intervention affects mortality and recurrence in patients with infective endocarditis.
Comparative analysis of early versus delayed surgical intervention in patients diagnosed with infective endocarditis.
Assessment of patient outcomes such as death, recurrence, and reoperation within one year.
Early surgical intervention did not increase the risk of death within one year.
No increased risk of recurrence or reoperation was observed within the same period.

Structured PICO

Does early surgical intervention improve the 1-year composite outcome in patients with infective endocarditis?

Population

166 patients diagnosed with definite infective endocarditis (IE) according to the latest Duke criteria who met indications for cardiac surgery, 74.7% male.

Intervention

Early surgical intervention (radical cardiac surgery within 1-7 days after admission)

Comparator

Delayed surgical intervention (cardiac surgery 8-13 days or 14-28 days after admission)

Outcome

Composite endpoint at 1 year (death from any cause, postoperative embolic event, recurrence of IE, postoperative valve dysfunction (PVD), and rehospitalization for heart failure)composite

Early surgical intervention (within 1-7 days) for infective endocarditis does not increase mortality or recurrence compared to delayed surgery, supporting early intervention before completing a full antibiotic course.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Early surgical intervention did not increase the risk of death in patients with IE, nor did it increase the risk of recurrence and reoperation within one year. Therefore, we recommend early surgical intervention before completing a cycle of antibiotics in patients with a clear diagnosis, unstable cardiac function, or risk of recurrent embolism.

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