January 10, 2026BMC Neurology0 citationsOpen Access

Association between age and angiographic vasospasm in mechanically ventilated patients with aneurysmal subarachnoid hemorrhage: a secondary analysis

JHJ B HuangFujian Medical University CCCunrong ChenFujian Medical University LTLin TianShanghai Ocean University

Key Result

In mechanically ventilated patients with aSAH, older patients (≥ 56 years) were less likely to develop angiographic vasospasm (OR 0.40, p = 0.017) compared to younger patients.

Key Points

To explore the association between age and angiographic vasospasm in mechanically ventilated patients with aneurysmal subarachnoid hemorrhage.
Conducted a retrospective analysis in a French university hospital ICU from 2010 to 2015.
Used univariate and multivariate logistic regression to identify factors associated with vasospasm.
Assessed the non-linear relationship between age and vasospasm with restricted cubic spline regression.
Evaluated threshold effects using a two-piecewise linear regression model.
Included 231 mechanically ventilated patients with aSAH, median age 56 years.
Rate of angiographic vasospasm was 34.63% (N = 80).
Older patients (≥ 56 years) less likely to develop vasospasm (OR 0.40; p = 0.017).
In patients aged ≤ 53 years, risk of vasospasm increased by 13% per yearly increase in age (OR 1.13; p = 0.002).
For patients aged > 53 years, risk decreased by 17% per yearly increase in age (OR 0.83; p < 0.001).

Structured PICO

Is age associated with the risk of angiographic vasospasm in mechanically ventilated patients with aneurysmal subarachnoid hemorrhage?

Population

231 mechanically ventilated patients with aneurysmal subarachnoid hemorrhage (aSAH), median age 56 years, 38.10% male, treated in the intensive care unit of a French university hospital.

Intervention

Older age (≥ 56 years) or continuous chronological age at hospital admission

Comparator

Younger age (< 56 years) or continuous chronological age

Outcome

Angiographic vasospasm (defined as a reduction of ≥ 1/3 in arterial diameter, assessed by computed tomography angiography or digital subtraction angiography)surrogate

In mechanically ventilated patients with aneurysmal subarachnoid hemorrhage, the risk of angiographic vasospasm has a non-linear relationship with age, peaking at 53 years and decreasing in older patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Background Age is defined as the patient’s chronological age (in years) at hospital admission. The association between age and angiographic vasospasm remains controversial. This study aimed to explore the association between age and angiographic vasospasm in mechanically ventilated patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods A secondary analysis was performed based on a retrospective study conducted from 2010 to 2015 in the intensive care unit (ICU) of a French university hospital. Factors associated with angiographic vasospasm were identified using univariate and multivariate logistic regression analyses. The non-linear relationship between age and angiographic vasospasm was assessed using restricted cubic spline regression, and the threshold effect was evaluated using a two-piecewise linear regression model. Results The study included 231 mechanically ventilated patients with aSAH. Their median age was 56 years (range, 19–84 years). Patients were divided into two groups based on the median age of 56 years: younger ( 53 years, the risk of angiographic vasospasm decreased by 17% for each year increase in age (OR, 0.83; 95% CI, 0.77–0.89; p < 0.001). Conclusion Age was non-linearly associated with the risk of angiographic vasospasm in mechanically ventilated patients with aSAH.

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