A left basal ganglia lesion in a 57‐year‐old patient

Figures

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  FIGURE 1. Axial T1 weighted brain MRI post‐contrast shows a peripherally, rim‐enhancing lesion within the left basal ganglia (arrow).

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  FIGURE 2. Histologically, the tumor consists predominantly of cells with abundant, variably granular cytoplasm. Microvascular proliferation (A) and brisk mitotic activity (A, inset) are present. The tumor is positive for GFAP (B) and OLIG2 in a subset (B, inset) and CD68 (C), the latter highlighting abundant lysosomes within the cells. CD163 is positive in background microglia/macrophages and negative in glioma cells (D). There is weak to moderate p53 overexpression in a subset of cells (E) and the Ki‐67 proliferation index is elevated up to ~5%–8% (F). Chromosomal microarray demonstrates combined chromosome gain of 7 and loss of 10 and CDKN2A/B homozygous loss (G).