Does moderate- to high-intensity lipid-lowering therapy reduce mortality risk in myocardial infarction patients aged 80 years and older compared to low-intensity therapy?
Moderate-to-high-intensity lipid-lowering therapy reduces 3-year mortality in post-MI patients over 80 years old, but this benefit is limited to those with a lower comorbidity burden (CCI ≤ 4).
Among MI patients aged over 80 years, moderate-to-high-intensity LLT significantly reduced mortality risk during 3-year follow-up compared to low-intensity LLT only in patients with CCI scores ≤ 4. Further investigation is required to optimize personalized lipid management through rigorous assessment of LLT benefits versus adverse effects.
Jiang et al. (Sun,) studied this question.