A spatiotemporally regulated drug delivery system with stage-specific thermosensitive gelation and photothermally triggered release for localized tumor therapy

Key Points

• The research aims to enhance drug delivery systems for localized tumor therapy using nanoparticles.
• Developed a spatiotemporally regulated drug delivery system.
• Combined injectable hydrogel and nanoparticles for localized delivery.
• Examined the thermosensitive gelation and photothermally triggered release for drug delivery.
• Localized drug delivery systems showed improved targeting efficiency.
• The system is designed to reduce systemic clearance of drugs.