Design, synthesis and evaluation of new pyrazino1′,2′:1,5pyrrolo2,3- d pyrimidines as tacrine-like acetylcholinesterase inhibitors

Key Points

• This research focuses on developing new inhibitors targeting acetylcholinesterase using pyrazino derivatives.
• Designed and synthesized eighteen pyrazino derivatives
• Evaluated compounds for acetylcholinesterase inhibition
• Compared new derivatives to known tacrine-like inhibitors
• Identified several pyrazino derivatives with enhanced acetylcholinesterase inhibitory activity
• Showed potential for therapeutic use similar to tacrine