Employing Cluster Transfer Strategy in Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Sensor for Nucleic Acid Detection

Siu Yee New; Nathaniel Jia Yoong Chan; Jessica Sui Ying Ooi

doi:10.1039/d5ay01362c

January 1, 2026Analytical Methods

Employing Cluster Transfer Strategy in Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Sensor for Nucleic Acid Detection

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Key Points

This research aims to improve nucleic acid detection methods using a novel cluster transfer strategy.
Utilized hybridisation chain reaction (HCR) for isothermal amplification.
Incorporated silver nanoclusters (AgNCs) for enhanced fluorescence detection.
Compared conventional methods with the new cluster transfer approach.
HCR improved nucleic acid detection sensitivity.
Cluster transfer strategy yielded higher fluorescence signals than conventional assays.

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Implication

Employing cluster transfer strategy enhances nucleic acid detection using hybridisation chain reaction and silver nanoclusters.

Abstract

Hybridisation chain reaction (HCR) is a robust isothermal amplification technique widely used for nucleic acid detection, often paired with silver nanoclusters (AgNCs) for fluorescence-based readouts. However, conventional HCR-AgNCs assays are...

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New et al. (2026) studied this question.

synapsesocial.com/papers/6966e72413bf7a6f02bff86a https://doi.org/10.1039/d5ay01362c

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Employing Cluster Transfer Strategy in Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Sensor for Nucleic Acid Detection

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Employing Cluster Transfer Strategy in Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Sensor for Nucleic Acid Detection

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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