Employing Cluster Transfer Strategy in Hybridisation Chain Reaction-Silver Nanoclusters Hybrid Sensor for Nucleic Acid Detection

Key Points

• This research aims to improve nucleic acid detection methods using a novel cluster transfer strategy.
• Utilized hybridisation chain reaction (HCR) for isothermal amplification.
• Incorporated silver nanoclusters (AgNCs) for enhanced fluorescence detection.
• Compared conventional methods with the new cluster transfer approach.
• HCR improved nucleic acid detection sensitivity.
• Cluster transfer strategy yielded higher fluorescence signals than conventional assays.