Multiscale Design Principles for Noncovalent Heteroaryl Phosphonate Inhibitors Targeting NDM-1

Key Points

• This research focuses on developing noncovalent inhibitors for NDM-1 to restore the efficacy of β-lactam antibiotics.
• Utilized multiscale design principles
• Focused on noncovalent heteroaryl phosphonate inhibitors
• Targeted New Delhi metallo-β-lactamase-1 (NDM-1)
• Identified effective molecular inhibitors
• Demonstrated potential to overcome resistance against β-lactam antibiotics