Advanced deep learning framework for breast cancer detection using digital breast tomosynthesis images

Abstract Objectives Early and accurate detection of breast cancer is critical for improving patient survival outcomes. This study proposes a robust deep learning–based framework for breast cancer detection using digital breast tomosynthesis (DBT) images, leveraging both single-slice and multi-slice inputs. Methods The proposed work includes image normalization, resizing and Laplacian Pyramid Enhancement (LPE). Various features were extracted and fused in different combinations. To retain the most discriminative features Exhaustive Feature Selection (EFS) is used. A hybrid model integrated using ResNet V2, MobileNet V3 and Inception V3+ for classification. Finally ensemble learning with XGBoost was applied and Hyperparameters were optimized using a grid search strategy. Results The hybrid model with multi-slice DBT inputs achieved better improvements with accuracy, sensitivity, specificity and area under the curve (AUC). While applying LPE, feature fusion and EFS substantially enhanced the hybrid model’s diagnostic performance. Conclusions The findings demonstrate the strong potential of advanced methods in enhancing performance. Future research work will focus on integrating this pipeline with clinical decision support systems, multi-center datasets and extending to other breast imaging modalities.