Objective To assess the efficacy and safety of Chaihu‐Guizhi‐Ganjiang decoction (CGGJD) combined with Danggui‐Shaoyao‐San (DS) in oligomenorrhea treatment. Methods In this prospective open‐label trial, 35 oligomenorrhea patients (30–40 years) received CGGJD‐DS for 3 months, followed by a 2‐month follow‐up. Outcomes included clinical efficacy rate, menstrual pattern and frequency, serum hormones (E2, LH, and FSH), uterine spiral artery indices (RI, PI, and S/D), endometrial blood flow parameters (VI, FI, and VFI), and endometrial thickness assessed pre‐/post‐treatment and post–follow‐up. Results Post‐treatment menstrual pattern and frequency both significantly increased versus baseline ( p < 0.01), with a 68.6% total efficacy rate. E2 levels significantly increased post‐treatment and post–follow‐up (both p < 0.01), while LH and FSH decreased significantly (both p < 0.01). Significant improvements occurred in spiral artery indices (all p < 0.01), endometrial blood flow parameters (all p < 0.01), endometrial blood distribution (Wald χ 2 = 20.8, p < 0.01), and endometrial thickness ( p < 0.01). No serious adverse events occurred. Conclusions CGGJD‐DS effectively improves ovarian function and endometrial perfusion in oligomenorrhea, demonstrating potential as an alternative therapy.
Yu et al. (Thu,) studied this question.
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