Solvent Accessible Surface Area Normalized Protein-Water Hydrogen Bonds Defines Protein Folded State Stability and Amyloid Formation

Key Points

• To explore how hydrogen bonds affect protein stability and amyloid formation.
• Conducted molecular dynamics simulations of various proteins.
• Analyzed solvent accessible surface area and protein-water hydrogen bonds.
• Evaluated the relationship between hydrogen bonds and protein stability across different SCOP fold classes.
• Found a correlation between hydrogen bonds and protein stability.
• Demonstrated that protein-water interactions influence amyloid formation.
• Identified specific hydrogen bond patterns associated with stable protein folded states.