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January 14, 2026Scientific Reports0 citationsOpen Access

Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells

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ACAllen Y. ChenARAlexander Y. Rudensky

Key Points

  • To investigate the effects of spontaneous Pten loss on T cell differentiation and responses during viral infections.
  • Used healthy mice with varying Pten expression levels.
  • Studied CD4 T cell differentiation towards T follicular helper cells.
  • Monitored T cell responses during acute viral infection.
  • Found that low Pten expression in T cells affects their differentiation.
  • Monoallelic Pten loss influences T follicular helper cell bias during infection.
  • Induced changes in T cell responses occurred without major autoimmune effects.

Abstract

Abstract We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses—without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6966f30613bf7a6f02c008abhttps://doi.org/10.1038/s41598-025-34754-1
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