Effect of statin use on prognostic outcomes in hepatocellular carcinoma following liver surgery: a systematic review and meta-analysis

This is a Meta-Analysis study (also classified as: Systematic Review).

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Key Points

This research aims to evaluate the effect of statin use on prognostic outcomes in hepatocellular carcinoma after surgical intervention.
Conducted a systematic review and meta-analysis of studies on statin use in HCC.
Included 15 studies with 37 160 patients undergoing surgical treatment.
Utilized the Newcastle-Ottawa Scale for quality assessment.
Calculated hazard ratios and 95% confidence intervals for survival outcomes.
Statins significantly improved overall survival (HR, 0.50; 95% CI, 0.40–0.61; P < 0.001).
Statin use was associated with improved recurrence-free survival (HR, 0.56; 95% CI, 0.49–0.65; P < 0.001).
The overall quality assessment revealed a low risk of bias.

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Systematic review shows statins improve long-term outcomes in hepatocellular carcinoma patients after surgery, suggesting an adjunctive therapy role.

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Saisa et al. (2025) studied this question.

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