Using quantitative pathologic analysis to identify microsatellite stability in digitized colorectal carcinoma images: An effort to screen patients who should be tested for Lynch syndrome.
Retrospective cohort study shows QuantCRC predicts microsatellite instability in colorectal cancer, indicating patients may need testing for Lynch syndrome.
Key Points
To identify differences in microsatellite stability among colorectal cancer patients using QuantCRC.
Conducted a retrospective cohort study at Mayo Clinic Arizona
Analyzed tumor characteristics using QuantCRC
Employed Receiver Operating Characteristic curve analysis to assess performance in identifying microsatellite instability
21.5% of 5132 colorectal cancer samples were MSI/dMMR
42.5% of MSI/dMMR cases had confirmed Lynch syndrome
QuantCRC AUC for predicting MSI/dMMR was 0.83 with 75% sensitivity and 79% specificity