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January 14, 2026Aging CellOpen Access

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

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Authors

XWX WangQZQian ZhangXZXiaomin Zhang

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Overview

Findings demonstrate SV2A reduces amyloid plaque in APP/PS1 mice, indicating a new target for Alzheimer's intervention.

Key Points

  • The research investigates how SV2A affects amyloid precursor protein (APP) processing and localization.
  • SV2A was overexpressed in APP/PS1 mice using adeno‐associated virus injections.
  • The effects on APP degradation were assessed in vivo and in vitro.
  • Subcellular distribution of APP was analyzed after SV2A overexpression.
  • SV2A overexpression significantly reduced Aβ plaque deposition in brain tissue.
  • SV2A was identified as a novel APP-binding protein that inhibits its interaction with BACE1.
  • SV2A shifted APP localization away from endosomal-lysosomal compartments.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6966f31d13bf7a6f02c00d28https://doi.org/10.1111/acel.70379
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