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January 14, 2026Wound Repair and Regeneration

TGF ‐β‐Dependent α11 Integrin Expression Is Reduced in Aging Gingival Wounds

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Authors

SRSusana RíosLTLishan TanVMValentina Muñoz

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Overview

Aging reduces signalling and α11 integrin expression in gingival fibroblasts, indicating impaired wound healing.

Key Points

  • To examine how aging affects the regulation of TGF-β-mediated α11 integrin expression in gingival repair.
  • Analyzed primary cultures of human gingival fibroblasts from young and aged donors using RT-qPCR and Western blot.
  • Assessed TGF-β isoforms and receptors and quantified TGF-β1 and TGF-β2 by ELISA.
  • Used gene reporter assays to evaluate TGF-β activity in different age groups.
  • Studied gingival wounds in young and aged mice regarding collagen deposition, organization, and α11 integrin expression.
  • Found reduced expression levels of α11 integrin and TGF-β1 in older compared to younger fibroblasts.
  • Showed that TGF-β1 treatment significantly increased α11 integrin mRNA and protein in younger donors but not in older ones.
  • Older mice exhibited lower collagen deposition and alignment, and diminished α11 integrin and TGF-β1 levels in gingival wounds.

Cite This Study

Ríos et al. (2026) studied this question.

synapsesocial.com/papers/6966f33b13bf7a6f02c012a0https://doi.org/10.1111/wrr.70122
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