Acrolein-integrated ESIPT probe for NIR fluorescence detection of cysteine with ultrafast response and sub-nanomolar sensitivity

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Key Points

This research aims to develop a fluorescence probe that can detect cysteine with high sensitivity and rapid response.
Integration of acrolein into the probe design.
Utilization of ESIPT (Excited-State Intramolecular Proton Transfer) mechanism.
Performance evaluation of the probe in NIR (Near-Infrared) fluorescence detection.
The probe demonstrated sub-nanomolar sensitivity for cysteine detection.
Detection response was achieved rapidly, indicating ultrafast response times.
Fluorescence intensity increased significantly in the presence of cysteine.

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Fluorescence probe detects cysteine with ultrafast response and high sensitivity, indicating potential biomedical applications.

Cysteine (Cys) is an essential sulfur-containing amino acid in the human body and is involved in many important physiological processes.

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Su et al. (2026) studied this question.

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