Acrolein-integrated ESIPT probe for NIR fluorescence detection of cysteine with ultrafast response and sub-nanomolar sensitivity

Key Points

• This research aims to develop a fluorescence probe that can detect cysteine with high sensitivity and rapid response.
• Integration of acrolein into the probe design.
• Utilization of ESIPT (Excited-State Intramolecular Proton Transfer) mechanism.
• Performance evaluation of the probe in NIR (Near-Infrared) fluorescence detection.
• The probe demonstrated sub-nanomolar sensitivity for cysteine detection.
• Detection response was achieved rapidly, indicating ultrafast response times.
• Fluorescence intensity increased significantly in the presence of cysteine.