Iron oxide nanoparticles hold significant potential for targeted hepatocyte delivery, provided that their physicochemical properties are carefully optimized to minimize off-target uptake by Kupffer cells and reduce hepatotoxicity. A comprehensive understanding of nanoparticle - cell interactions, iron homeostasis, and the impact of surface engineering is essential for the rational design of safer and more effective nanocarriers. Future progress will depend on balancing hepatocyte-specific targeting with biocompatibility, enabling the translational application of iron oxide nanoparticles in the diagnosis and treatment of liver diseases.
Sheptulina et al. (Mon,) studied this question.