What question did this study set out to answer?

To validate the effects of 40-Hz auditory stimulation on Alzheimer’s disease in a nonhuman primate model.

January 15, 2026Proceedings of the National Academy of Sciences0 citationsOpen Access

Reply to Song et al.: Acidity-sensitive chemistry promotes sulfate formation in East Asia

YLYu‐Chi LinNational Research Institute of Chinese Medicine SHShohei HattoriEarth Science Institute of the Slovak Academy of Sciences SISyuichi ItahashiKyushu University

Key Points

To validate the effects of 40-Hz auditory stimulation on Alzheimer’s disease in a nonhuman primate model.
Applied 40-Hz auditory stimulation on nine aged rhesus monkeys
Monitored neurological responses of the subjects
Demonstrated potential therapeutic effects on Alzheimer’s disease
Established a pathway for translational research from rodents to primates

Abstract

Although 40-Hz physical stimulation shows therapeutic potential for Alzheimer’s disease (AD) in rodents, translational validation in nonhuman primates is critical. We applied 40-Hz auditory stimulation on nine aged rhesus monkeys and monitored ...Based mainly on rodents studies, forty-hertz (40-Hz) physical stimulation has been regarded as a potential noninvasive treatment for Alzheimer’s disease (AD). Considering the brain differences between rodents and humans, the effects of 40-Hz physical ...

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