What type of study is this?

This is a Systematic Review study.

What question did this study set out to answer?

This review aims to explore the associations between particulate matter exposure and oxidative stress across various omic technologies.

January 15, 2026Respiratory ResearchOpen Access

Multi-omics of oxidative stress and particulate matter exposure: a systematic review

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This review aims to explore the associations between particulate matter exposure and oxidative stress across various omic technologies.
Conducted a systematic review of studies from January 2021 to March 2024.
Included studies assessing the effects of particulate matter on oxidative stress in adult populations.
Evaluated risk of bias using the Newcastle–Ottawa Scale and Cochrane’s.
A total of 77 studies were analyzed.
Particulate matter exposure was linked to increased oxidative stress markers across multiple omics layers.
Metabolomics studies revealed changes in pro-oxidant metabolites and antioxidant pathways.
Evidence of differential gene methylation related to oxidative stress and inflammation was noted.
Gut microbiota composition was altered towards a pro-oxidative profile due to particulate matter exposure.

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Implication

Systematic review demonstrates particulate matter exposure increases oxidative stress biomarkers, indicating significant health risks in cardiovascular and metabolic diseases.

Cite This Study

Fallahzadeh et al. (2026) studied this question.

synapsesocial.com/papers/69683e135818e7dbd7c63213 https://doi.org/10.1186/s12931-025-03487-0

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Implication

Systematic review demonstrates particulate matter exposure increases oxidative stress biomarkers, indicating significant health risks in cardiovascular and metabolic diseases.

Multi-omics of oxidative stress and particulate matter exposure: a systematic review

Key Points

Discussion

Implication

Cite This Study

Multi-omics of oxidative stress and particulate matter exposure: a systematic review

Key Points

Discussion

Implication

Cite This Study

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