What is the clinical evidence from this study?

Study design: Observational. Population: healthy Caucasian adults (n=721). Intervention: Cardiovascular Magnetic Resonance (CMR) imaging. Primary outcome: Mitral annular diameter.

What does this research mean for the field?

Mean end-diastolic mitral annular diameter is 2.9 ± 0.4 cm in men and 2.6 ± 0.4 cm in women aged 45–74 years in a healthy Caucasian population. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 6, 2021Open Access

Cardiovascular magnetic resonance reference values of mitral and tricuspid annular dimensions: the UK Biobank cohort

Key Result

Cardiovascular magnetic resonance imaging revealed that mean end-diastolic mitral annular diameter was 2.9 ± 0.4 cm in men and 2.6 ± 0.4 cm in women in participants aged 45–74 years.

Study Design

Type

Observational (n=721)

Multicenter

Structured PICO

Population

721 healthy Caucasian adults aged 45-74 years (mean age 59 ± 7 years, 54% women) from the UK Biobank cohort. Key exclusions: non-Caucasian ethnicity, known cardiovascular disease, hypertension, respiratory disease, diabetes mellitus, hyperlipidemia, hematological disease, renal disease, rheumatological disease, malignancy, symptoms of chest pain or dyspnea, current- or ex-tobacco smokers, BMI ≥ 30 kg/m2, and valvular heart disease of any type and severity.

Outcome

Age- and sex-specific cardiovascular magnetic resonance (CMR) reference ranges for mitral annular (MA) and tricuspid annular (TA) dimensions and tethering indicessurrogate

This study establishes age- and sex-specific CMR reference ranges for mitral and tricuspid annular dimensions in healthy Caucasian adults, providing essential normative data for evaluating valvular heart disease.

Limitations

The reference ranges may not be generalizable to other ethnic or age groups.

Abstract

We described age- and sex-specific reference ranges of MA and TA dimensions and tethering indices in the largest validated healthy Caucasian population. Reference ranges presented in this study may help to improve the distinction between normal and pathological states, prompting the identification of subjects that may benefit from advanced cardiac imaging for annular sizing and planning of valvular interventions.

Bookmark

View Full Paper