Key result
Early AVR is linked to ~57% lower mortality versus observation in moderate AS and LVSD.
Why the study?
Does early surgical aortic valve replacement reduce all-cause death in patients with moderate aortic stenosis and left ventricular systolic dysfunction?
Cohort (n=255)
No
Does early surgical aortic valve replacement reduce all-cause death in patients with moderate aortic stenosis and left ventricular systolic dysfunction?
Effect estimate: HR 0.43 (95% CI 0.20–0.91)
Absolute Event Rate: 5.03% vs 18.8%
p-value: p=0.028
Early surgical aortic valve replacement in patients with moderate aortic stenosis and left ventricular systolic dysfunction is associated with a significantly lower risk of all-cause mortality compared to medical observation.
Early AVR was associated with lower mortality in moderate AS with LVSD; challenges consensus and leaves open need for RCTs.
In patients with moderate AS and LVSD, AVR reduces the risk of all-cause death. A prospective randomized trial is warranted to confirm our findings.
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Moon et al. (2020) conducted a cohort in Moderate aortic stenosis and left ventricular systolic dysfunction (n=255). Aortic valve replacement (AVR) vs. Medical observation (no AVR) was evaluated on All-cause death (HR 0.43, 95% CI 0.20–0.91, p=0.028). Early aortic valve replacement reduced the risk of all-cause death by 57% compared to medical observation in patients with moderate aortic stenosis and left ventricular systolic dysfunction.
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