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January 16, 2026Journal of Clinical Medicine3 citationsOpen Access

Aortic Valve Stenosis: Progress from Diagnosis to Treatment

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POP OssolaSGSimone GhidiniEGElena Gualini

Key Result

Contemporary management of aortic valve stenosis relies on multimodality imaging for diagnosis and tailored interventional strategies, including SAVR and TAVR, to optimize patient outcomes.

Key Points

  • The research aims to investigate the progression of aortic stenosis and effective treatment methods.
  • Utilized transthoracic echocardiography for diagnosis and assessment of stenosis severity.
  • Identified the impact of comorbidities on disease progression and myocardial damage.
  • Reviewed treatment options, including surgical and transcatheter interventions.
  • Highlighted the importance of advanced imaging techniques for accurate risk stratification.
  • Aortic stenosis often leads to ventricular hypertrophy and impaired heart function.
  • Advanced imaging is frequently needed due to discordant grading from standard procedures.
  • Both surgical and transcatheter approaches are effective, but tailored management is crucial in complex cases.
  • Contemporary care relies on integrating advanced imaging and personalized interventions to improve patient outcomes.

PICO

P
Population
Aortic Valve Stenosis

Abstract

Aortic stenosis (AS) is the most prevalent valvular heart disease in Western countries and it is especially associated with older age. With its progressive course, AS leads to ventricular hypertrophy, impaired diastolic and systolic function, and symptomatic deterioration. The natural history of AS is closely linked to the extent of myocardial and extracardiac damage in association with the patients comorbidities. Diagnosis relies primarily on transthoracic echocardiography, which assesses valve morphology, quantifies stenosis severity, and evaluates cardiac remodeling. However, discordant grading is frequent, necessitating advanced imaging to clarify the severity and the mechanism of the stenosis and stratify risk. Treatment is predominantly interventional, as no medical therapy is able to stop disease progression. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) are the two treatment options. Special clinical scenarios—such as cardiogenic shock or concomitant cardiac amyloidosis—pose additional diagnostic and therapeutic challenges and require individualized, multidisciplinary management. Overall, contemporary AS care increasingly integrates multimodality imaging, refined risk stratification, and tailored interventional strategies to optimize outcomes.

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Cite This Study

Ossola et al. (2026) conducted a review in Aortic Valve Stenosis. Contemporary management of aortic valve stenosis relies on multimodality imaging for diagnosis and tailored interventional strategies, including SAVR and TAVR, to optimize patient outcomes.

synapsesocial.com/papers/6969d428940543b977709042https://doi.org/10.3390/jcm15020659
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