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January 16, 2026Open Access

Effectiveness of simplified ART regimens in older adults living with HIV: real-world evidence from a Brazilian cohort

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Authors

PSP.V. StanickiKTK.I. TascaWZW.R. Zimmerman

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Overview

Observational cohort study evaluates ART regimens, revealing improved outcomes in older adults living with HIV, indicating the need for tailored treatment strategies.

Key Points

  • To assess the effectiveness of traditional versus simplified antiretroviral therapy regimens in older adults living with HIV.
  • Observational cohort study design
  • Track 1,018 individuals treated in Brazil
  • Compare outcomes between older adults (≥50 years) and younger adults (18-49 years)
  • Multivariate analysis to determine correlations with clinical outcomes
  • Older adults achieved higher undetectable viral load rates (89.4% vs 83.2%, P<0.006)
  • Fewer cases of virological failure in older adults (2.5% vs 10.1%; P<0.0001)
  • Significantly greater CD4+ T-cell counts in older adults (P=0.0012)
  • Improved clinical outcomes strongly correlated with simplified treatment regime and longer treatment duration

Cite This Study

Stanicki et al. (2026) studied this question.

synapsesocial.com/papers/6969d428940543b9777090c4https://doi.org/10.1590/1414-431x2025e14994
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