ABSTRACT Severe traumas such as traffic accidents, industrial accidents, natural disasters, and wars occur frequently, and such traumas are often accompanied by massive arterial bleeding. In the case of arterial bleeding, timely hemostasis is extremely crucial. In this study, we developed a high‐strength composite cryogel (SA/SF/DA) by combining the water‐absorbing properties of sodium alginate (SA) with the hemostatic properties of silk fibroin (SF) and polydopamine (PDA). The interconnected network and hydrophilicity of the cryogel accelerate the absorption of water from blood, concentrating red blood cells and platelets to form a primary thrombus. In addition, the release of calcium ions (Ca 2 + ) from the cryogel framework promotes the physical crosslinking of blood cells through electrostatic interactions. The functional groups of Ca 2 + and PDA further interact with adhered platelets, activating them and accelerating the production of thrombin, which converts fibrinogen into fibrin to accelerate blood clot formation. These mechanisms work synergistically to enhance hemostatic performance. In rat liver transverse incision and femoral artery bleeding models, compared with other groups, the SA/SF/DA group showed significantly shortened hemostasis time and reduced blood loss. This high‐strength composite cryogel provides a promising new approach for the development of rapid hemostatic materials.
Yu et al. (Thu,) studied this question.
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